统计与管理学院2017年学术报告第52期

【主  题】Estimating Time-Varying Directed Gene Regulation Networks

【报告人】曹际国, 副教授

Simon Fraser University, Canada

【时  间】 2017年07月11日（星期二）16:00－17:00

【地  点】 上海财经大学统计与管理学院大楼1208室

【摘  要】The problem of modeling the dynamical regulation process within a gene network has been of great interest for a long time. We propose to model this dynamical system with a large number of nonlinear ordinary differential equations (ODEs), in which the regulation function is estimated directly from data without any parametric assumption. Most current research assumes the gene regulation network is static, but in reality, the connection and regulation function of the network may change with time or environment. This change is reflected in our dynamical model by allowing the regulation function varying with the gene expression and forcing this regulation function to be zero if no regulation happens. We introduce a statistical method called functional SCAD to estimate a time-varying sparse and directed gene regulation network, and, simultaneously, to provide a smooth estimation of the regulation function and identify the interval in which no regulation effect exists. The finite sample performance of the proposed method is investigated in a Monte Carlo simulation study. Our method is demonstrated by estimating a time-varying directed gene regulation network of 20 genes involved in muscle development during the embryonic stage of Drosophila melanogaster.

【邀请人】 黄涛