统计与管理学院2017年学术报告第40期

【主  题】Seamless phase II/III clinical trials with frequentist response adaptive randomization

【报告人】Hongjian Zhu, 助教授

University of Texas Health Science Center at Houston

【时  间】 2017年06月09日（星期五）16:00－17:00

【地  点】 上海财经大学统计与管理学院大楼1312室

【摘  要】Seamless phase II/III clinical trials have attracted increasing attention recently.

They mainly use Bayesian response adaptive randomization (RAR) designs.

There has been little research into seamless clinical trials using frequentist RAR designs because of the difficulty in performing valid statistical inference and controlling the type I error rate for this procedure. Well-designed frequentist RAR can target theoretically optimal allocation proportions, and they have explicit asymptotic results. We propose a family of frequentist RAR designs for seamless phase II/III clinical trials, study its asymptotic properties, and investigate how to control the type I error rate. The numerical studies demonstrate that the type I error rate can be well controlled with the proposed method and certain ethical and efficient objectives can be achieved using the proposed design.

【邀请人】 黄涛